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Associate Professor Liang Xiaoyun's latest SSCI findings: metabolic abnormalities and colorectal cancer risk

Published: 2017-02-23

 
Recently, the latest research of our institute associate professor Liang Xiaoyun “The poor metabolic status increased colorectal cancer risk: a normal weight in postmenopausal women in the study” was published in the International Journal of Cancer Biomarkers & Epidemiology professional Prevention (SSCI, Q1).
 
The study argues that if women have two or more of hyperlipidemia, hyperglycemia, hypertension and low levels of high-density lipoprotein cholesterol (ie, "good cholesterol"), even if these women are normal, Also in a higher risk of colorectal cancer.
 
In postmenopausal women with normal weight, the risk of developing colorectal cancer was 49% higher than that of the normal metabolism. The current colorectal cancer screening is mainly based on age, if you can identify high-risk individuals based on metabolic status, you can prevent the occurrence of colorectal cancer or early diagnosis of colorectal cancer.
 
Dr. Luo Juhua, associate professor at the school of public health at the University of Indiana, Principal Investigator, said: "even if you have a normal body weight, you need to understand the metabolic status". The study, which included postmenopausal women of 50-79 years old with normal weight, said: "the findings can be drawn to men or young women, but further studies are needed to verify the results of the study," Luo Juhua said".
 
Dr. Andrew Chan is an Associate Professor of Gastroenterology at Harvard Medical School. He argues that the study's research question is another way, and that metabolic risk factors other than weight are closely related to colorectal cancer.
 
The American Cancer Society data show that the incidence of colorectal cancer in women ranks third in all cancers and ranks fourth in China. Overweight or obesity is a known risk factor for colorectal cancer, and the proportion of metabolic abnormalities in adults with normal weight is as high as 30%. However, the relationship between metabolic abnormalities and colorectal cancer risk is rarely involved in research of normal weight groups.
 
The study used data from the women's Health Initiative (Women 's Health Initiative), a study of 5068 women, funded by the National Institutes of Health (NIH).
 
Why do women with normal weight and abnormal metabolism have a higher risk of colorectal cancer? The reason is not clear. One possible explanation is that poor metabolic conditions can trigger inflammation that can lead to cancer risk. Dr. Andrew Chan said the study provides another evidence for the population to maintain a healthy lifestyle. 
 
 
The study was reported by HealthDay, HealthCanal, MedPage Today and other media, and was reprint by US News & World Report, MedicineNet and other media in the meantime.
 
 
 
consumer.healthday.com/cancer-information-5/colon-cancer-news-96/heart-risks-may-boost-women-s-colon-cancer-risk-too-719272.html
 
 
Info of the paper
Liang X, Margolis KL, Hendryx M, Rohan T, Groessl EJ, Thomson CA, Kroenke CH, Simon M, Lane D, Stefanick M, Luo J. Metabolic phenotype and risk of colorectal cancer in normal-weight postmenopausal women. Cancer Epidemiology Biomarkers & Prevention. 2017 Feb 1. doi: 10.1158/1055-9965.EPI-16-0761. [Epub ahead of print]
 
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